Pixley Seme was born on 1 October 1881 at the Inanda Mission in Natal, the son of Isaka Sarah (nee Mseleku) Seme. He attended primary school at the local mission school where the American Congregationalist missionary, Reverend S. C. Pixley, took an interest in him and arranged for him to go to the Mount Hermon School in Massachusetts in the USA.
From Columbia he went to Oxford University where he completed a degree in Law. He was called to the bar at the Middle Temple in London before returning to South Africa on the eve of the creation of the Union of South Africa in 1910.
These posts and others on past ANC presidents complement exhibitions at the Local History Museums, including a Josiah Gumede exhibition at KwaMuhle Museum and the Pixley ka Isaka Seme exhibition at the Old Courthouse Museum.